Bioactive Compounds in Native Cocoa (Theobroma cacao L.)

R Rojas, B Cabanillas, R Portales… - Native Crops in Latin …, 2022 - taylorfrancis.com
… foods like cheese, yogurt, bread, wine, and chocolate. These compounds possess various
biological activities including … Salsolinol is a tetrahydroisoquinoline that can be found in …

[HTML][HTML] Mood components in cocoa and chocolate: the mood pyramid

E Tuenter, K Foubert, L Pieters - Planta medica, 2018 - thieme-connect.com
… from the fruits of the cocoa tree Theobroma cacao, have a long-… Salsolinol can be present
as a racemate in cocoa and … level, the tetrahydro-isoquinoline alkaloids, more in particular …

[HTML][HTML] Anti-inflammatory and anti-nociceptive effects of cocoa: a review on future perspectives in treatment of pain

M De Feo, A Paladini, C Ferri, A Carducci, R Del Pinto… - Pain and Therapy, 2020 - Springer
… of biological activities, including anti-inflammatory and analgesic … This tetrahydroisoquinoline
alkaloid is a dopaminergic active … The analgesic action of salsolinol seems to also involve a …

The effect of cocoa-rich products on depression, anxiety, and mood: A systematic review and meta-analysis

L Fusar-Poli, A Gabbiadini, A Ciancio… - Critical reviews in …, 2022 - Taylor & Francis
Chocolate and cocoa are products derived from cocoa beans, the seeds of the Theobroma
cacaoCocoa is a complex food and contains several biological compounds. Of note, during …

[HTML][HTML] Salsolinol—neurotoxic or Neuroprotective?

M Kurnik-Łucka, G Latacz, A Martyniak, A Bugajski… - Neurotoxicity …, 2020 - Springer
… role of (RS)-salsolinol in the mood effects of cocoa. The D 3 -… racemate) was sufficient to
reach a pharmacologically relevant … (RS)-salsolinol is one of the many tetrahydroisoquinoline

Neuroprotective Activity of Enantiomers of Salsolinol and N-Methyl-(R)-salsolinol: In Vitro and In Silico Studies

M Kurnik-Łucka, G Latacz, A Bucki, M Rivera-Meza… - ACS …, 2023 - ACS Publications
Salsolinol (1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol) … Clearly, in vitro, SAL also exerts
its biological action in a dose-… are present in vivo, (2) about 3% of NMSAL was found to be …

[PDF][PDF] Anti-Inflammatory and Anti-Nociceptive Effects of Cocoa: A Review on Future Perspectives in Treatment of Pain

MDFAP Claudio, FA Carducci - 2020 - researchgate.net
… of biological activities, including anti-inflammatory and analgesic … This tetrahydroisoquinoline
alkaloid is a dopaminergic active … The analgesic action of salsolinol seems to also involve a …

[HTML][HTML] Biomarkers of intake for tropical fruits

N Vázquez-Manjarrez, M Ulaszewska, M Garcia-Aloy… - Genes & Nutrition, 2020 - Springer
… The identified candidate biomarkers were subject to validation evaluation using eight biological
Salsolinol is also highly present in cocoa powder (25 μg/g) and chocolate (19 μg/g) [80]. …

[HTML][HTML] Identification of the beer component hordenine as food-derived dopamine D2 receptor agonist by virtual screening a 3D compound database

T Sommer, H Hübner, A El Kerdawy, P Gmeiner… - Scientific reports, 2017 - nature.com
product library ZBC turned out rather to possess drug-like … from 0.094 (pyrraline) to 0.324
(salsolinol), while we obtained T c … of cocoa and chocolate 37 , whereas hordenine is present in …

[HTML][HTML] Stereoselectivity in the membrane transport of phenylethylamine derivatives by human monoamine transporters and organic cation transporters 1, 2, and 3

L Gebauer, M Rafehi, J Brockmöller - Biomolecules, 2022 - mdpi.com
… its receptor is presented in many pharmacology textbooks (eg, [… Concerning stereoselectivity,
we observed similar patterns as … Salsolinol is found as racemate in cocoa and cocoa-based …